Photosensitizer drug delivery via an optical fiber

…, BI Kruft, A Ghogare, D Aebisher, A Greer

Index: Zamadar, Matibur; Ghosh, Goutam; Mahendran, Adaickapillai; Minnis, Mihaela; Kruft, Bonnie I.; Ghogare, Ashwini; Aebisher, David; Greer, Alexander Journal of the American Chemical Society, 2011 , vol. 133, # 20 p. 7882 - 7891

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Citation Number: 25

Abstract

An optical fiber has been developed with a maneuverable mini-probe tip that sparges O2 gas and photodetaches pheophorbide (sensitizer) molecules. Singlet oxygen is produced at the probe tip surface which reacts with an alkene spacer group releasing sensitizer upon fragmentation of a dioxetane intermediate. Optimal sensitizer photorelease occurred when the probe tip was loaded with 60 nmol sensitizer, where crowding of the pheophorbide ...