Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl) guanidines

…, VA Horne, JP Huggins, E King, M O'Gara…

Index: Fish, Paul V.; Barber, Christopher G.; Brown, David G.; Butt, Richard; Collis, Michael G.; Dickinson, Roger P.; Henry, Brian T.; Horne, Valerie A.; Huggins, John P.; King, Elizabeth; O'Gara, Margaret; McCleverty, Dawn; McIntosh, Fraser; Phillips, Christopher; Webster, Robert Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2341 - 2351

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Citation Number: 49

Abstract

1-Isoquinolinylguanidines were previously disclosed as potent and selective inhibitors of urokinase-type plasminogen activator (uPA). Further investigation of this template has revealed that incorporation of a 7-sulfonamide group furnishes a new series of potent and highly selective uPA inhibitors. Potency and selectivity can be achieved with sulfonamides derived from a variety of amines and is further enhanced by the incorporation of ...