Tetrahedron letters

Direct regioselective phenylation of acridine derivatives by phenyllithium

B Dutta, GK Kar, JK Ray

Index: Dutta, Bishnupada; Kar, Gandhi K.; Ray, Jayanta K. Tetrahedron Letters, 2003 , vol. 44, # 48 p. 8641 - 8643

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Citation Number: 15

Abstract

Alkylation of acridine and acridine derivatives improves their solubility in common organic solvents. 1 Direct phenylation of acridine and its derivatives using phenyllithium would generate phenylacridines which are building blocks/motifs of various polycyclic natural and unnatural products. 1. and 2. Michael type 1,4-addition of phenyllithium to the pyridine nucleus leads to the only product isolated from the reaction mixture. Direct phenylation will further help to ...

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