New heteroarylbenzenesulphonamides as matrix metalloproteinase inhibitors

F Delbecq, G Cordonnier, N Pommery, D Barbry…

Index: Delbecq, Frederic; Cordonnier, Guy; Pommery, Nicole; Barbry, Didier; Henichart, Jean-Pierre Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 5 p. 1119 - 1121

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Citation Number: 12

Abstract

A series of derivatives of 2, 4-and 2, 5-thiazolyl-or oxazolylbenzenesulphonamides has been prepared and evaluated as potential MMP inhibitors. The thiazole 15b have been found to exhibit MMP-2 and MMP-9 inhibitions higher than reference compounds GI 129471 and CGS 27023A.