Identification of isoflavone derivatives as effective anticryptosporidial agents in vitro and in vivo

AV Stachulski, NG Berry, AC Lilian Low…

Index: Stachulski, Andrew V.; Berry, Neil G.; Low, Lilian A.C.; Moores, Shelley L.; Row, Eleanor; Warhurst, David C.; Adagu, Ipemida S.; Rossignol, Jean-Francois Journal of Medicinal Chemistry, 2006 , vol. 49, # 4 p. 1450 - 1454

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Citation Number: 80

Abstract

We report the preparation and antiparasitic activity in vitro and in vivo of a series of isoflavone derivatives related to genistein. These analogues retain the 5, 7- dihydroxyisoflavone core of genistein: direct genistein analogues (2-H isoflavones), 2- carboethoxy isoflavones, and the precursor deoxybenzoins were all evaluated. Excellent in vitro activity against Cryptosporidium parvum was observed for both classes of isoflavones ...