Chiral Lewis Base Catalyzed Highly Enantioselective Reduction of N??Alkyl β??Enamino Esters with Trichlorosilane and Water

…, Y Li, C Wang, L Zhou, X Lu, J Sun

Index: Wu, Xinjun; Li, Yang; Wang, Chao; Zhou, Li; Lu, Xiaoxia; Sun, Jian Chemistry - A European Journal, 2011 , vol. 17, # 10 p. 2846 - 2848

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Citation Number: 49

Abstract

Enantiomerically pure β-amino acid derivatives are important chiral building blocks for the synthesis of biologically active molecules, such as β-peptides and β-lactams.[1] Among the various methods for the synthesis of these targets, catalytic asymmetric reduction of β- enamino esters represents one of the most efficient and straightforward approaches.[2] During the past decade, a number of transitionmetal catalytic systems have been ...

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