Tetrahedron: Asymmetry

An efficient new enzymatic method for the preparation of β-aryl-β-amino acid enantiomers

G Tasnádi, E Forró, F Fülöp

Index: Tasnadi, Gabor; Forro, Eniko; Fueloep, Ferenc Tetrahedron Asymmetry, 2008 , vol. 19, # 17 p. 2072 - 2077

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Citation Number: 33

Abstract

An efficient synthesis of β-aryl-β-amino acid enantiomers has been developed via the lipase- catalysed enantioselective hydrolysis of the corresponding racemic ethyl esters in an organic solvent. High enantioselectivities (E> 100) were observed when the lipase PS- catalysed reactions were performed with H2O (0.5 equiv) in diisopropyl ether at 45° C. The products could be easily separated and were obtained in good yields of⩾ 40%.

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