Highly efficient copper-catalyzed O-arylation using readily available (S)-N-methylpyrrolidine-2-carboxamide as the ligand

X Liu, H Fu, Y Jiang, Y Zhao

Index: Liu, Xianghao; Fu, Hua; Jiang, Yuyang; Zhao, Yufen Synlett, 2008 , # 2 p. 221 - 224

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Citation Number: 6

Abstract

The ligand (S)-N-methylpyrrolidine-2-carboxamide hydrochloride (Pro-NHMe·HCl) was readily synthesized according to the reported procedure. [15] We optimized the catalysis conditions for O-arylation including the choice of catalysts, bases, solvents and other additives. The experiments showed that the catalyst system containing 10 mol% of CuI and 20 mol% of Pro-NHMe hydrochloride relative to aryl halide in the presence of K 3 PO 4 in DMF with 3% H 2 O could give the ...