An Eco??Friendly Asymmetric Organocatalytic Conjugate Addition of Malonates to α, β??Unsaturated Aldehydes: Application on the Synthesis of Chiral Indoles

…, AM Deobald, S Narayanaperumal…

Index: Feu, Karla Santos; Deobald, Anna Maria; Narayanaperumal, Senthil; Correa, Arlene G.; Weber Paixao, Marcio European Journal of Organic Chemistry, 2013 , # 26 p. 5917 - 5922

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Citation Number: 4

Abstract

Abstract The asymmetric Michael addition of malonates to α, β-unsaturated aldehydes using a modified Jørgensen–Hayashi organocatalyst in EtOH: brine solvent media is reported. The procedure proceeds smoothly to afford the corresponding Michael adducts in good yields with excellent enantioselectivities. The resulting Michael adducts represent excellent building blocks for the synthesis of chiral indoles.

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