Design, synthesis, and DNA-binding of N-alkyl (anilino) quinazoline derivatives

…, S Ravez, P Six, MH David-Cordonnier…

Index: Garofalo, Antonio; Goossens, Laurence; Baldeyrou, Brigitte; Lemoine, Amelie; Ravez, Severine; Six, Perrine; David-Cordonnier, Marie-Helene; Bonte, Jean-Paul; Depreux, Patrick; Lansiaux, Amelie; Goossens, Jean-Francois Journal of Medicinal Chemistry, 2010 , vol. 53, # 22 p. 8089 - 8103

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Citation Number: 28

Abstract

New N-alkylanilinoquinazoline derivatives 5, 12, 20, and 22 have been prepared from 4- chloro-6, 7-dimethoxyquinazoline 3, 4-chloro-6, 7-methylenedioxyquinazoline 19, and commercially available anilines. Differents classes of compounds substituted by an aryloxygroup (6a− c, 16a, b, and 17a, b),(aminophenyl) ureas (12a, b and 13a− f), anilines (4a− m, 20a, b), N-alkyl (aniline)(5a− m, 21a, b, 22a, d), and N-aminoalkyl (aniline)(22e− g ...

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