Tetrahedron

A new approach towards the synthesis of 3-amino-6-(hetero) arylpyridazines based on palladium catalyzed cross-coupling reactions

…, GLF Lemiere, R Dommisse, K Augustyns, A Haemers

Index: Maes, Bert U. W.; Lemiere, Guy L. F.; Dommisse, Roger; Augustyns, Koen; Haemers, Achiel Tetrahedron, 2000 , vol. 56, # 12 p. 1777 - 1781

Full Text: HTML

Citation Number: 77

Abstract

The synthesis of 3-amino-6-(hetero) arylpyridazines via palladium catalyzed cross-coupling reactions (Suzuki, Stille) on 3-amino-6-chloropyridazine (1a) and 3-amino-6-iodopyridazine (1b) has been investigated. Comparison of the results shows that there is no need to start from 1b. An improved method for the synthesis of compound 1b from 1a is also described.

Related Articles:

Synthesis and structure-activity relationships of a series of aminopyridazine derivatives of. gamma.-aminobutyric acid acting as selective GABA-A antagonists

[Journal of Medicinal Chemistry, , vol. 30, # 2 p. 239 - 249]

Synthesis of Aminopyridazines from Azidopyridazines and Tetrazolo [1, 5-b] pyridazines

[Kappe, Th.; Pfaffenschlager, A.; Stadlbauer, W. Synthesis, 1989 , # 9 p. 666 - 671]

Synthesis and structure-activity relationships of a series of aminopyridazine derivatives of. gamma.-aminobutyric acid acting as selective GABA-A antagonists

[Journal of Medicinal Chemistry, , vol. 30, # 2 p. 239 - 249]

On the amination of azaheterocycles. A new procedure for the introduction of an amino group

[Journal of Heterocyclic Chemistry, , vol. 19, p. 1285 - 1287]

Synthesis of Aminopyridazines from Azidopyridazines and Tetrazolo [1, 5-b] pyridazines

[Synthesis, , # 9 p. 666 - 671]

More Articles...