Biocatalytic Racemization of (Hetero) Aryl??aliphatic α??Hydroxycarboxylic Acids by Lactobacillus spp. Proceeds via an Oxidation–Reduction Sequence

…, M Hall, W Kroutil, R Stuermer, B Hauer…

Index: Nestl, Bettina M.; Glueck, Silvia M.; Hall, Melanie; Kroutil, Wolfgang; Stuermer, Rainer; Hauer, Bernhard; Faber, Kurt European Journal of Organic Chemistry, 2006 , # 20 p. 4573 - 4577

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Citation Number: 18

Abstract

Abstract The biocatalytic racemization of a range of (hetero) aryl-and (di) aryl-aliphatic α- hydroxycarboxylic acids has been achieved by using whole resting cells of Lactobacillus spp. The essentially mild (physiological) reaction conditions ensure the suppression of undesired side reactions, such as elimination, decomposition or condensation. Cofactor/inhibitor studies using a cell-free extract of Lactobacillus paracasei DSM 20207 ...

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