Molecules

Toxicity assessments of chalcone and some synthetic chalcone analogues in a zebrafish model

…, TH Fong, HM Chen, CY Chang, YH Wang, CY Chern…

Index: Lee, Ya-Ting; Fong, Tsorng-Harn; Chen, Hui-Min; Chang, Chao-Yuan; Wang, Yun-Hsin; Chern, Ching-Yuh; Chen, Yau-Hung Molecules, 2014 , vol. 19, # 1 p. 641 - 650

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Citation Number: 7

Abstract

Abstract: The aim of this study was to investigate the in vivo toxicities of some novel synthetic chalcones. Chalcone and four chalcone analogues 1a–d were evaluated using zebrafish embryos following antibody staining to visualize their morphological changes and muscle fiber alignment. Results showed that embryos treated with 3'-hydroxychalcone (compound 1b) displayed a high percentage of muscle defects (96.6%), especially myofibril ...