Tetrahedron

Lipophilic peptide nucleic acids containing a 1, 3-diyne function: synthesis, characterization and production of derived polydiacetylene liposomes

NM Howarth, WE Lindsell, E Murray, PN Preston

Index: Howarth, Nicola M.; Lindsell, W. Edward; Murray, Euan; Preston, Peter N. Tetrahedron, 2005 , vol. 61, # 37 p. 8875 - 8887

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Citation Number: 17

Abstract

Adenine-, cytosine-and thymine-containing peptide nucleic acid (PNA) monomers have been synthesized in which either diacetylenic or stearoyl moieties are attached to the N-or C- terminus; the diacetylenic group is embedded within a long hydrocarbon chain. A range of analogous lipophilic functionalized PNA oligomers have been prepared using either solid phase synthesis or a post-synthetic solution phase procedure following cleavage of the ...