Water soluble, hydrolytically stable derivatives of the antitumor drug titanocene dichloride and binding studies with nucleotides

G Mokdsi, MM Harding

Index: Mokdsi, George; Harding, Margaret M. Journal of Organometallic Chemistry, 1998 , vol. 565, # 1-2 p. 29 - 35

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Citation Number: 68

Abstract

The rate of hydrolysis of the aromatic rings of Cp2TiX2 and the dimethylsubstituted derivatives (MeCp) 2TiX2 [X= Cl, O2CCH2NH3Cl], in aqueous solutions at pH 2–8 have been studied by 1H-NMR spectroscopy. Rapid hydrolysis of both the halide and cyclopentadienyl ligands in Cp2TiX2 [X= Cl, O2CCH2NH3Cl] occurs to give predominantly insoluble precipitates at pH 7. In contrast, under the same experimental conditions, the ...