Greatly simplified procedures for the synthesis of α-amino acids by the direct alkylation of pseudoephedrine glycinamide hydrate

AG Myers, P Schnider, S Kwon…

Index: Myers, Andrew G.; Schnider, Patrick; Kwon, Soojin; Kung, Daniel W. Journal of Organic Chemistry, 1999 , vol. 64, # 9 p. 3322 - 3327

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Citation Number: 87

Abstract

A modified procedure for the synthesis of highly enantiomerically enriched α-amino acids is described that involves the direct alkylation of pseudoephedrine glycinamide hydrate (1⊙ H2O) followed by hydrolysis. The modified procedure was developed to overcome several inconvenient aspects of our earlier reported procedure. Advantages of the new method include (1) a greatly simplified one-step synthesis of the alkylation substrate (1⊙ H2O) by ...