Convenient One-Pot Synthesis of 2-Oxazolines from Carboxylic Acids

K Hioki, Y Takechi, N Kimura, H Tanaka…

Index: Hioki, Kazuhito; Takechi, Yumiko; Kimura, Noriyo; Tanaka, Hiroyuki; Kunishima, Munetaka Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 12 p. 1735 - 1737

Full Text: HTML

Citation Number: 5

Abstract

Simple one-pot methods for preparation of 2-oxazolines have been developed using 4-(4, 6- dimethoxy-1, 3, 5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM). Treatment of a mixture of carboxylic acids and 2-haloethylammonium salts with DMT-MM in methanol followed by refluxing in the presence of KOH gives oxazolines.

Related Articles:

Silica sulfuric acid as an efficient catalyst for the preparation of 2H-indazolo [2, 1-b] phthalazine-triones

[Csampai; Kormendy; Ruff Tetrahedron, 1991 , vol. 47, # 25 p. 4457 - 4464]

Alkenes from halides and epoxides by reductive eliminations with CrII complexes

[Kochi,J.K. et al. Tetrahedron, 1968 , vol. 24, p. 3503 - 3515]

More Articles...