Design, synthesis, and biological evaluation of novel trifluoromethyl indoles as potent HIV-1 NNRTIs with an improved drug resistance profile

HX Jiang, DM Zhuang, Y Huang, XX Cao…

Index: Organic and Biomolecular Chemistry, , vol. 12, # 21 p. 3446 - 3458

Full Text: HTML

Citation Number: 7

Abstract

... Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy ... NNRTIs was based on the Merck derivative L-737, 126 (1) 12 as a ... The carcinogenicity (predicted by CISOC-PSCT) 21 of compounds 10e, 10l, 10i, 10k, 10j ...

Related Articles:

Extending the versatility of the Hemetsberger–Knittel indole synthesis through microwave and flow chemistry

[Ranasinghe, Nadeesha; Jones, Graham B. Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1740 - 1742]

Intramolecular CH amination reactions: Exploitation of the Rh2 (II)-catalyzed decomposition of azidoacrylates

[Journal of the American Chemical Society, , vol. 129, # 24 p. 7500 - 7501]

Probing the subpockets of factor Xa reveals two binding modes for inhibitors based on a 2-carboxyindole scaffold: a study combining structure-activity relationship and …

[Journal of Medicinal Chemistry, , vol. 48, # 14 p. 4511 - 4525]

Regioselective and versatile synthesis of indoles via intramolecular Friedel-Crafts heteroannulation of enaminones

[Synlett, , # 5 p. 749 - 755]

Regioselective and versatile synthesis of indoles via intramolecular Friedel-Crafts heteroannulation of enaminones

[Synlett, , # 5 p. 749 - 755]

More Articles...