Tetrahedron letters

Direct synthesis of N-substituted, functionalized aspartic acids using alkali maleates and amines

PS Piispanen, PM Pihko

Index: Piispanen, Peter S.; Pihko, Petri M. Tetrahedron Letters, 2005 , vol. 46, # 16 p. 2751 - 2755

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Citation Number: 5

Abstract

A practical and general one-pot synthesis of mono-N-substituted, functionalized aspartic acids has been developed. The N-substituted aspartic acids are formed directly from alkali maleates and primary amines in hot DMSO. Products from several different primary amines can be prepared chemoselectively in moderate to good yields.