Analogues of γ??aminobutyric acid (GABA) and trans??4??aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists

…, RJ Vandenberg, GAR Johnston

Index: Allan; Johnston; Twitchin Australian Journal of Chemistry, 1980 , vol. 33, # 5 p. 1115 - 1122

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Citation Number: 30

Abstract

6 It was concluded that substitution of a methyl or a halo group in the C2 position of GABA or TACA is tolerated at GABAC receptors. However, there was dramatic loss of activity when these groups were substituted at the C3, C4 and nitrogen positions of GABA and TACA. 7