Potent, orally active inhibitors of lipoprotein-associated phospholipase A 2: 1-(biphenylmethylamidoalkyl)-pyrimidones

HF Boyd, SCM Fell, DMB Hickey, RJ Ife…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 1 p. 51 - 55

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Citation Number: 25

Abstract

... Please enable JavaScript to use all the features on this page. Bioorganic & Medicinal Chemistry Letters. ... Whilst the statins have achieved both medical and commercial success in this role, 1 they are only particularly effective in about 30% of patients. ...

Inhibitors of NF-κB and AP-1 Gene Expression: SAR Studies on the Pyrimidine Portion of 2-Chloro-4-trifluoromethylpyrimidine-5-[N-(3', 5'-bis (trifluoromethyl) phenyl) …

[Palanki; Erdman; Gayo-Fung; Shevlin; Sullivan; Goldman; Ransone; Bennett; Manning; Suto Journal of medicinal chemistry, 2000 , vol. 43, # 21 p. 3995 - 4004]

Potent, orally active inhibitors of lipoprotein-associated phospholipase A 2: 1-(biphenylmethylamidoalkyl)-pyrimidones

Abstract

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