2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 adenosine receptors

…, ME Olah, GL Stiles, KA Jacobson

Index: Kim; Ji; Siddiqi; Olah; Stiles; Jacobson Journal of Medicinal Chemistry, 1994 , vol. 37, # 21 p. 3614 - 3621

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Citation Number: 200

Abstract

Adenosine derivatives bearing an W-(3-iodobenzyl) group, reported to enhance the afinity of adenosine-5'-uronamide analogues as agonists at A3 adenosine receptors (J. Med. Chem. 1994, 37, 636-646), were synthesized starting from methyl PD-ribofuranoside in 10 steps. Binding affinities at A1 and Aza receptors in rat brain membranes and at cloned rat & receptors from stably transfected CHO cells were compared. W-(3-Iodobenzyl) adenosine ...

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