Steroids CCXXVIII. The synthesis of equilin

JA Zderic, H Carpio, A Bowers, C Djerassi

Index: Zderic,J.A. et al. Steroids, 1963 , vol. 1, p. 233 - 249

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Citation Number: 16

Abstract

The conversion of 19-nortestosterone acetate into 19-norandrosta-4, 7-diene-3, 17-dione (X) is described. The latter compound is transformed directly into equilin by a microbiological dehydrogenation process with Cor~ nebacteriumsimplex, thus representing the first synthesis of this important female sex hormone. Alternate attempts to synthesise equilin are discussed.