Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study

JFF Liegeois, FA Rogister, J Bruhwyler…

Index: Liegeois; Rogister; Bruhwyler; Damas; Thuy Phuong Nguyen; Inarejos; Chleide; Mercier; Delarge Journal of Medicinal Chemistry, 1994 , vol. 37, # 4 p. 519 - 525

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Citation Number: 79

Abstract

Dibenzazepine derivatives have represented and still represent today an interesting and exciting field of investigation in medicinal chemistry. l-16 A slight modification of the tricyclic structure leads to a profound alteration of the activity profile. Indeed, clothiapine (1) is a typicalne~ roleptic'~ with a strong propensity to induce extrapyramidal symptoms (EPS), while clozapine (2) and fluperlapine (3) show an atypical antipsychotic profilela21 and ...