Synthesis of α, β-Unsaturated Aldehydes Based on a One-Pot Phase-Switch Dehydrogenative Cross-Coupling of Primary Alcohols

…, L De Luca, M Taddei, JMJ Williams, A Porcheddu

Index: Porcheddu, Andrea; Mura, Manuel G.; De Luca, Lidia; Pizzetti, Marianna; Taddei, Maurizio Organic Letters, 2012 , vol. 14, # 23 p. 6112 - 6115

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Citation Number: 11

Abstract

An efficient one-pot ruthenium-catalyzed hydrogen-transfer strategy for a direct access to α, β-unsaturated aldehydes has been developed. The employment of enolates prepared in situ from alcohols avoided handling unstable aldehydes and provided a very appealing route to different cinnamaldehydes substituted in position 2. A silica-grafted amine was used as phase-switch tag leading to a selective one-pot process in favor of cross-dehydrogenative ...

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