Mass spectrometry imaging in drug development

A Nilsson, RJA Goodwin, M Shariatgorji…

Index: Shariatgorji, Mohammadreza; Nilsson, Anna; Goodwin, Richard J. A.; Svenningsson, Per; Schintu, Nicoletta; Banka, Zoltan; Kladni, Laszlo; Hasko, Tibor; Szabo, Andras; Andren, Per E. Analytical Chemistry, 2012 , vol. 84, # 16 p. 7152 - 7157

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Citation Number: 32

Abstract

Drug discovery and development is a high-risk, expensive endeavor and it commonly takes about 10− 15 years to obtain marketing approval from project inception. 1 Research efforts during the early stages of the process aim to generate and support pharmaceutically relevant hypotheses, for example, that the inhibition or activation of a protein or pathway will have a positive therapeutic effect in a particular disease state. These studies lead to the ...