1-Substituted 4-(3-hydroxyphenyl) piperazines are pure opioid receptor antagonists

FI Carroll, JP Cueva, JB Thomas…

Index: Janetka, James W.; Furness, M. Scott; Zhang, Xiaoyan; Coop, Andrew; Folk, John E.; Mattson, Mariena V.; Jacobson, Arthur E.; Rice, Kenner C. Journal of Organic Chemistry, 2003 , vol. 68, # 10 p. 3976 - 3980

Full Text: HTML

Citation Number: 7

Abstract

... Select a Journal or Book ... Center for Organic and Medicinal ... a (a) 3-Bromoanisole, Pd 2 (dba) 3 , KOtBu, P(tBu) 3 , toluene, 100 °C, 18 h; (b) KN(Si(CH 3 ) 3 ) 2 , 3-bromoanisole, 1,4-dioxane 100 °C, 2 h; (c) BBr 3 , CH 2 Cl 2 , −78 °C, 4 h; (d) HBr (48%) reflux; (e) C 6 H 5 (CH 2 ...

Enantioconvergent Synthesis of (-)-(2R, 5 S)-1-Allyl-2, 5-dimethylpiperazine, an Intermediate to δ-Opioid Receptor Ligands