A series of 2-arylamino-5-(indolyl)-1, 3, 4-thiadiazoles as potent cytotoxic agents

D Kumar, NM Kumar, B Noel, K Shah

Index: Kumar, Dalip; Kumar, N. Maruthi; Noel, Brett; Shah, Kavita European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 432 - 438

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Citation Number: 21

Abstract

A series of 2-arylamino-5-(indolyl)-1, 3, 4-thiadiazoles 6a–v were prepared and studied for their anticancer activity against selected human cancer cell lines. The reaction of indolylhydrazides 3a–h with a variety of aryl isothiocyanates 4 afforded the key intermediate thiosemicarbazides 5a–v, which upon treatment with acetyl chloride produced the 2- arylamino-5-(indolyl)-1, 3, 4-thiadiazoles 6a–v in good yields. Most of the synthesized ...

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