Synthesis of new heterocyclic hybrids based on pyrazole and thiazolidinone scaffolds as potent inhibitors of tyrosinase

…, SC Warangkar, BP Bandgar, CN Khobragade

Index: Gawande, Shrikant S.; Warangkar, Suchita C.; Bandgar, Babasaheb P.; Khobragade, Chandrahasya N. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 10 p. 2772 - 2777

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Citation Number: 17

Abstract

As a part of ongoing studies in developing new Tyrosinase inhibitors, a class of structurally novel 2-(2, 4-dimethoxy phenylamino)-5 methylene-4-thiazolinone derivatives were synthesized by incorporating 2-(2, 4-dimethoxy-phenylamino)-thiazol-4-one with various 1- (1-methyl-buta-1, 3-dienyl)-3-phenyl-1H-pyrazole-4-carbaldehyde. The results showed that some of the synthesized compounds exhibited significant inhibitory activities. Especially, 5 ...