Lipophilic 5, 6, 7, 8-tetrahydropterin substrates for phenylalanine hydroxylase (monkey brain), tryptophan hydroxylase (rat brain) and tyrosine hydroxylase (rat brain)

…, H Taguchi, RGH Cotton, S Battiston, L Leong

Index: Armarego, Wilfred L. F.; Taguchi, Hiroyasu; Cotton, Richard G. H.; Battiston, Sandra; Leong, Lillian European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 283 - 292

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Citation Number: 10

Abstract

Abstract A high yielding unambiguous synthesis of (±)-6-alkyl-5, 6, 7, 8-tetrahydropterin 5a–f hydrochlorides starting from ethyl α-isocyanoacetate 1 and the respective alkanoic anhydrides or alkanoyl chlorides in four steps is described. All the six pterins 5a–f that have been synthesised are substrates for mammalian phenylalanine, tryptophan and tyrosine hydroxylases and their activities have been compared with those of natural 6R- ...