Domino Vilsmeier–Haack/ring closure sequences: a facile synthesis of 3-chlorobenzo [b] thiophene-2-carbaldehydes

N Paul, S Muthusubramanian

Index: Paul, Nidhin; Muthusubramanian, Shanmugam Tetrahedron Letters, 2011 , vol. 52, # 29 p. 3743 - 3746

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Citation Number: 11

Abstract

Abstract Vilsmeier's reagent treatment of substituted diphenacyl sulfides or diphenacyl disulfides has led to the formation of a series of benzfused 3-chlorothiophene-2- carbaldehydes by a Domino Vilsmeier–Haack reaction/ring closure sequence, opening a new route for the synthesis of 3-chlorobenzo [b] thiophene-2-carbaldehydes and their benzfused analogues. A plausible mechanism has been proposed.