2-(2-Arylvinyl)-7-substituted-quinazolin-4 (3H)-ones: Synthesis, reactions and antimicrobial activity

S El-Meligie, AK El-Ansary, MM Said, MMM Hussein

Index: El-Meligie; El-Ansary; Said; Hussein Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001 , vol. 40, # 1 p. 62 - 69

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Citation Number: 12

Abstract

Abstract: 7-Chloro-3-(4-hydroxyphenyl)-2-methylquinazolin-4 (3H)-one 3a on condensation with ethyl chloroformate, epichlorhydrin and isocyanates gives 7-chloro-3-[4- ethoxyearbonyloxy) phenyl]-2-methylquinazolin-4 (3H)-one 4a, 7-chloro-3-[4-(2, 3- epoxypropoxy) phenyl]-2-methylquinazolin-4 (3H)-ones 5a and 7-chloro-3-[4-(substituted amino carbonyloxy) phenyl]-2-methylquinazolin-4-(3H-ones) 6a, b, respectively which on ...