Tetrahedron letters

Synthesis of optically active ring-A substituted tryptophans as IDO inhibitors

X Li, W Yin, PVVS Sarma, H Zhou, J Ma, JM Cook

Index: Li, Xiaoyan; Yin, Wenyuan; Sarma, P.V.V. Srirama; Zhou, Hao; Jun Ma; Cook, James M. Tetrahedron Letters, 2004 , vol. 45, # 46 p. 8569 - 8573

Full Text: HTML

Citation Number: 35

Abstract

Indoleamine 2,3-dioxygenase (IDO) is a monomeric cytosolic enzyme that is distributed in many human tissues including the lens, brain, lung, kidney, spleen, and in macrophages. 1 It is a heme-containing enzyme that uses superoxide or oxygen to cleave the 2,3-double bond of the pyrrole ring of l-tryptophan to yield N-formylkynurenine. This is the first and rate-determining step of the kynurenine pathway (KP), which is the major metabolic path for the breakdown ...

Related Articles:

Hydrogen bonding in substituted nitroanilines: hydrogen-bonded sheets in 4-iodo-3-nitroaniline

[Garden, Simon J.; Wardell, James L.; Skakle, Janet M. S.; Low, John N.; Glidewell, Christopher Acta Crystallographica, Section C: Crystal Structure Communications, 2004 , vol. 60, # 5 p. O328 - O330]

Interplay of hydrogen bonds, iodo⋯ nitro interactions and aromatic π⋯ π stacking interactions in iodo-nitroanilines

[Acta Crystallographica Section B: Structural Science, , vol. 58, # 4 p. 701 - 709]

Effect of the electronic structure of the radical anions of 4-substituted 1, 2-and 1, 3-dinitrobenzenes on the regioselectivity of reduction of the nitro groups

[Russian Journal of General Chemistry, , vol. 76, # 1 p. 76 - 81]

Iodination of aromatic amines with iodine and silver sulfate

[Synthetic Communications, , vol. 22, # 22 p. 3215 - 3219]

More Articles...