Synthesis of 1, 2, 3, 4-tetrahydroisoquinolines containing electron-withdrawing groups

GJ Quallich, TW Makowski, AF Sanders…

Index: Quallich, George J.; Makowski, Teresa W.; Sanders, Andrew F.; Urban, Frank J.; Vazquez, Enrique Journal of Organic Chemistry, 1998 , vol. 63, # 12 p. 4116 - 4119

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Citation Number: 38

Abstract

Synthesis of tetrahydroisoquinolines containing electronwithdrawing groups in the aryl ring was required for the preparation of novel pharmaceutical agents. Unfortunately, many of the isoquinoline (Pomeranz-Fritsch) 1, dihydroisoquinoline (Bischler-Napieralski), 2 and ...

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