Structure–activity relationships of xanthene carboxamides, novel CCR1 receptor antagonists

…, M Ishikawa, K Matsuda, K Ohwaki, T Saeki…

Index: Naya, Akira; Ishikawa, Makoto; Matsuda, Kenji; Ohwaki, Kenji; Saeki, Toshihiko; Noguchi, Kazuhito; Ohtake, Norikazu Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 6 p. 875 - 884

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Citation Number: 52

Abstract

The structure–activity relationships of xanthene carboxamide derivatives on the CCR1 receptor binding affinity and the functional antagonist activity were described. Previously, we reported a quaternarized xanthen-9-carboxamide 1 as a potent human CCR1 receptor antagonist that was derived from a xanthen-9-carboxamide lead 2a. Further derivatization of 2a focusing on installing an additional substituent into the xanthene ring resulted in the ...

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