An N-aroyltransferase of the BAHD superfamily has broad aroyl CoA specificity in vitro with analogues of N-dearoylpaclitaxel

…, YA Mengistu, IN Nawarathne, KD Walker

Index: Nevarez, Danielle M.; Mengistu, Yemane A.; Nawarathne, Irosha N.; Walker, Kevin D. Journal of the American Chemical Society, 2009 , vol. 131, p. 5994 - 6002

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Citation Number: 12

Abstract

The native N-debenzoyl-2′-deoxypaclitaxel: N-benzoyltransferase (NDTBT), from Taxus plants, transfers a benzoyl group from the corresponding CoA thioester to the amino group of the β-phenylalanine side chain of N-debenzoyl-2′-deoxypaclitaxel, which is purportedly on the paclitaxel (Taxol) biosynthetic pathway. To elucidate the substrate specificity of NDTBT overexpressed in Escherichia coli, the purified enzyme was incubated with ...

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