Tetrahedron

Application of the vicinal oxyamination reaction with asymmetric induction to the hemisynthesis of taxol and analogues

…, MT Adeline, D Guenard, F Guéritte-Voegelein…

Index: Mangatal; Adeline; Guenard; Gueritte-Voegelein; Potier Tetrahedron, 1989 , vol. 45, # 13 p. 4177 - 4190

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Citation Number: 209

Abstract

Taxol, 10-deacetyl taxol and their related side chain analogues can be obtained via a “Sharpless” oxyamination reaction on 13-cinnamoyl baccatin III. Asymmetric induction has been studied using different bridgehead amines as chiral ligands. This procedure constitutes an alternative route to taxol derivatives for biological studies.

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