Design and synthesis of orally active inhibitors of TNF synthesis as anti-rheumatoid arthritis drugs

…, J Huang, F Chu, E Eugui, A Mirkovich, Y Kim…

Index: Chen, Jian Jeffrey; Dewdney, Nolan; Lin, Xiaohong; Martin, Robert L.; Walker, Keith A. M.; Huang, Jane; Chu, Frances; Eugui, Elsie; Mirkovich, Anna; Kim, Yong; Sarma, Keshab; Arzeno, Humberto; Van Wart, Harold E. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3951 - 3954

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Citation Number: 13

Abstract

A novel series of TNF inhibitors was identified based on the screening of existing MMP inhibitor libraries. Further SAR optimization led to the discovery of a novel lead compound. Its synthesis, efficacy in experimental animal models, and pharmacokinetic data are discussed.

Synthesis and biological evaluation of 1-(isoxazol-5-ylmethylaminoethyl)-4-phenyl tetrahydropyridine and piperidine derivatives as potent T-type calcium channel …

[Lee, Ju-Hyeon; Seo, Seon Hee; Lim, Eun Jeong; Cho, Nam-Chul; Nam, Ghilsoo; Kang, Soon Bang; Pae, Ae Nim; Jeong, Nakcheol; Keum, Gyochang European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 246 - 257]

Synthesis and biological evaluation of 1-(isoxazol-5-ylmethylaminoethyl)-4-phenyl tetrahydropyridine and piperidine derivatives as potent T-type calcium channel …

Design and synthesis of orally active inhibitors of TNF synthesis as anti-rheumatoid arthritis drugs

Abstract

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