Studies towards the conception of new selective PPARβ/δ ligands

…, B Staels, DH Caignard, C Dacquet, P Renard…

Index: Ekambome Bassene, Carine; Suzenet, Franck; Hennuyer, Nathalie; Staels, Bart; Caignard, Daniel-Henri; Dacquet, Catherine; Renard, Pierre; Guillaumet, Gerald Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 17 p. 4528 - 4532

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Citation Number: 16

Abstract

In order to define new PPARβ/δ ligands, SAR study on the selective PPARβ/δ activator L- 165,041 led to the identification of one key functional group for selective PPARβ/δ activation. Furthermore, taking advantage of SAR studies done elsewhere on the most selective PPARβ/δ ligand GW501516, the conception of new ligands showing good affinity for PPARβ/δ is reported. Finally, synthesis and biological evaluation of pyridine analogues ...

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