Tetrahedron letters

Silyl group deprotection by Pd/C/H 2. A facile and selective method

S Kim, SM Jacobo, CT Chang, S Bellone, WS Powell…

Index: Kim, Seongjin; Jacobo, Sheila Marie; Chang, Chih-Tsung; Bellone, Sophie; Powell, William S.; Rokach, Joshua Tetrahedron Letters, 2004 , vol. 45, # 9 p. 1973 - 1976

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Citation Number: 17

Abstract

An easy, high yield, RT, short-reaction-time Pd/C hydrogenation of silyl groups is described. This includes TES, TPS, TBS, TBDMS, TIPS, and TBDPS. The relative selectivity of the process has been investigated and we can show, for example, that TES, TPS, TBS, and TBDMS removal can be performed in the presence of TIPS and TBDPS.

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