[(3-Aryl-1, 2-benzisoxazol-6-yl) oxy] acetic acids. A new diuretic series

GM Shutske, LL Setescak, RC Allen…

Index: Shutske, Gregory M.; Setescak, Linda L.; Allen, Richard C.; Davis, Larry; Effland, Richard C.; et al. Journal of Medicinal Chemistry, 1982 , vol. 25, # 1 p. 36 - 44

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Citation Number: 33

Abstract

Chemistry. The synthesis of benzisoxazoles has been reviewed? Most of the (1, 2- benzisoxazol) oxyacetic acids (13, Table I) were synthesized from 2-chlorobenzophenones 6 and 7 (Scheme I), which were obtained from appropriately substituted 3-chloroanisoles and aroyl chlorides under typical Friedel-Crafts conditions. The hydroxybenzophenones 6 were obtained either in two steps through the intermediacy of the methoxybenzophenones ...