Synthesis and biological evaluation of new active For??Met??Leu??Phe??OMe analogues containing para??substituted Phe residues

…, F Feliciani, A Stefanucci, R Costante…

Index: Mollica, Adriano; Feliciani, Federica; Stefanucci, Azzurra; Costante, Roberto; Lucente, Gino; Pinnen, Francesco; Notaristefano, Daniela; Spisani, Susanna Journal of Peptide Science, 2012 , vol. 18, # 6 p. 418 - 426

Full Text: HTML

Citation Number: 7

Abstract

The chemotactic agent N-formyl-L-methionyl-L-leucyl-L-phenylalanine (For-Met-Leu-Phe; fMLF) can be isolated from bacterial suspensions and can also be found in disrupted mitochondria [1, 2]. This small N-acyl tripeptide is the prototype and the most active component of a family of N-formyl-methionyl peptides that act as molecular switches capable to trigger the directional migration (chemotaxis) towards the infection sites of human ...