An efficient synthesis of coumestrol and coumestans by iodocyclization and Pd-catalyzed intramolecular lactonization
T Yao, D Yue, RC Larock
Index: Yao, Tuanli; Yue, Dawei; Larock, Richard C. Journal of Organic Chemistry, 2005 , vol. 70, # 24 p. 9985 - 9989
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Citation Number: 113
Abstract
The total synthesis of coumestrol has been reported by several groups using quite different approaches. 5 However, most of the reported syntheses have required multiple steps, and produced only modest overall yields. Recently, a number of naturally occurring coumestan isoflavones have been discovered, 6 and their biological effects are currently under investigation. 7 In view of the many important physiological effects that estrogens have on the human body and ...
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