An in-depth study of the biotransformation of nitriles into amides and/or acids using Rhodococcus rhodochrous AJ270 1

O Meth-Cohn, MX Wang

Index: Meth-Cohn, Otto; Wang, Mei-Xiang Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 8 p. 1099 - 1104

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Citation Number: 88

Abstract

A variety of aliphatic, aromatic and heterocyclic nitriles have been readily hydrolysed into the corresponding amides and/or acids under very mild conditions using Rhodococcus sp. AJ270. The nitrile hydratase involved in this novel nitrile-hydrolysing microorganism efficiently hydrates most nitriles tested, irrespective of the electronic and steric effects of the substituents, to form the amides. Conversion of amides into acids catalysed by the ...

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