Synthesis and biological characterization of novel hybrid 7-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-propyl-amino}-5, 6, 7, 8-tetrahydro-naphthalen-2-ol and their …

…, SK Venkataraman, XS Fei, R Kolhatkar…

Index: Dutta, Aloke K.; Venkataraman, Sylesh K.; Fei, Xiang-Shu; Kolhatkar, Rohit; Zhang, Shijun; Reith, Maarten E.A. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 16 p. 4361 - 4373

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Citation Number: 36

Abstract

In a recent preliminary communication we described the development of a series of hybrid molecules for the dopamine D2 and D3 receptor subtypes. The design of these compounds was based on combining pharmacophoric elements of aminotetralin and piperazine molecular fragments derived from known dopamine receptor agonist and antagonist molecules. Molecules developed from this approach exhibited high affinity and selectivity ...

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