Quantitative structure–activity analyses of novel hydroxyphenylurea derivatives as antioxidants

…, H Kubota, M Yasuhara, Y Hashimura, T Suzuki…

Index: Nakao, Kazuya; Shimizu, Ryo; Kubota, Hitoshi; Yasuhara, Mikiko; Hashimura, Yoshimasa; Suzuki, Toshikazu; Fujita, Toshio; Ohmizu, Hiroshi Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 6 p. 849 - 868

Full Text: HTML

Citation Number: 37

Abstract

A series of substituted hydroxyphenylureas was synthesized, the chemical structure of which was designed based on structures of natural antioxidants, vitamin E (α-tocopherol) and uric acid. They exhibited high inhibitory activity against lipid peroxidation. In order to gain an insight into the mechanism of the inhibition reaction, we analyzed their structure–activity relationships quantitatively. Electronic and steric effects of substituents on the phenolic ...

Related Articles:

Synthesis and biological characterization of novel hybrid 7-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-propyl-amino}-5, 6, 7, 8-tetrahydro-naphthalen-2-ol and their …

[Dutta, Aloke K.; Venkataraman, Sylesh K.; Fei, Xiang-Shu; Kolhatkar, Rohit; Zhang, Shijun; Reith, Maarten E.A. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 16 p. 4361 - 4373]

A novel series of hybrid compounds derived by combining 2-aminotetralin and piperazine fragments: Binding activity at D 2 and D 3 receptors

[Dutta, Aloke K; Fei, XiangShu; Reith, Maarten E.A Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 4 p. 619 - 622]

More Articles...