Organic letters

Synthesis of ether oligomers

O Renaudet, JL Reymond

Index: Renaudet, Olivier; Reymond, Jean-Louis Organic Letters, 2004 , vol. 6, # 3 p. 397 - 400

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Citation Number: 10

Abstract

Hydroxyaromatic aldehydes and ketones were used as building blocks to prepare ether oligomers. An iterative two-step protocol involving Mitsunobu coupling and carbonyl reduction provided a protecting-group-free route with high yields. Activity screening of an 84- member library against proteases led to the discovery of micromolar inhibitors for trypsin, chymotrypsin, and subtilisin.

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