Medicinal Chemistry Research

Synthesis and evaluation of the hypoglycemic and hypolipidemic activity of novel 5-benzylidene-2, 4-thiazolidinedione analogs in a type-2 diabetes model

S Mehendale-Munj, R Ghosh, CS Ramaa

Index: Mehendale-Munj, Sonali; Ghosh, Rumi; Ramaa Medicinal Chemistry Research, 2011 , vol. 20, # 5 p. 642 - 647

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Citation Number: 11

Abstract

Abstract This article reports synthesis and evaluation of two novel thiazolidinedione ring containing molecules namely (Z)-5-(2-(4-((2, 4-dioxothiazolidin-5-ylidene) methyl) phenoxy) acetyl)-2-hydroxybenzamide (4) and (Z)-2-(4-((2, 4-dioxothiazolidin-5-ylidene) methyl) phenoxy)-N-(5-nitrothiazol-2-yl) acetamide (7). The new chemical entities were tested for hypoglycemic activity and for their total cholesterol (CHL) and triglyceride (TG) lowering ...