Synthesis of highly functionalized anthraquinones and evaluation of their antitumor activity

…, KM Gericke, I Schuberth

Index: Tietze, Lutz F.; Gericke, Kersten M.; Schuberth, Ingrid European Journal of Organic Chemistry, 2007 , # 27 p. 4563 - 4577

Full Text: HTML

Citation Number: 19

Abstract

Abstract Highly functionalized anthraquinones which derive from the natural products mensacarcin, islandicin, and chrysophanol have been efficiently synthesized using a Diels– Alder reaction as key step. The introduction of the proposed pharmacophoric side chain unit has been achieved by an addition of an aryllithium species onto different aldehydes. Furthermore, the antitumor activity of these novel compounds has been studied by the in ...

Related Articles:

Regioselective synthesis of islandicin and digitopurpone

[Wiseman, John R.; Pendery, John J.; Otto, Charlotte A.; Chiong, Kaolin G. Journal of Organic Chemistry, 1980 , vol. 45, # 3 p. 516 - 519]

Substitution of quinizarin and 5-hydroxyquinizarin at C-2

[Sutherland, James K.; Towers, Patrick; Greenhalgh, Colin W. Journal of the Chemical Society, Chemical Communications, 1981 , # 15 p. 740 - 741]

Polycyclic hydroxyquinones. 13. A novel synthesis of islandicin and digitopurpone

[Cano, Pilar; Echavarren, Antonio; Prados, Pilar Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5373 - 5376]

Regioselective synthesis of islandicin and digitopurpone

[Wiseman, John R.; Pendery, John J.; Otto, Charlotte A.; Chiong, Kaolin G. Journal of Organic Chemistry, 1980 , vol. 45, # 3 p. 516 - 519]

Biosynthetic-studies on tajixanthone and shamixanthone, polyketide hemiterpenoid metabolites of Aspergillus variecolor

[Ahmed, Salman A.; Bardshiri, Esfandiar; McIntyre, C. Rupert; Simpson, Thomas J. Australian Journal of Chemistry, 1992 , vol. 45, # 1 p. 249 - 274]

More Articles...