Pharmaceutica Acta Helvetiae

Investigations on the influence of 2′-O-alkyl modifications on the base pairing properties of oligonucleotides

D Werner, H Brunar, CR Noe

Index: Werner, Doris; Brunar, Helmut; Noe, Christian R. Pharmaceutica Acta Helvetiae, 1998 , vol. 73, # 1 p. 3 - 10

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Citation Number: 13

Abstract

The antisense strategy has gained wide acceptance as a promising drug development concept. Antisense drugs hybridize with selected complementary sequences in a highly specific manner. However, as a main prerequisite for extensive therapeutic use of this new class of drugs, selected structural modifications are required to adjust pharmacokinetic and pharmacodynamic behavior. In continuation of our earlier investigations on 2′-O- ...